Dawei Zhang;Shimin Xu;Liping H. Pettus;Andrew Tasker;Partha Chakrabarti;Rob M. Rzasa;Kelvin K. C. Sham
发明人:
Andrew Tasker,Dawei Zhang,Liping H. Pettus,Rob M. Rzasa,Kelvin K. C. Sham,Shimin Xu,Partha Chakrabarti
申请号：
US11899363
公开号：
US08101612B2
申请日:
2007.09.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of p38 kinase mediated diseases and related inflammatory conditions. The compounds have a general Formula IIwherein L1, L2, R1a, R1b, R1c, R2, R3, R3a, R4, R5 and p are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
