Andrew Tasker;Ryan Wurz;Shimin Xu;Liping H. Pettus
发明人:
Liping H. Pettus,Andrew Tasker,Shimin Xu,Ryan Wurz
申请号：
US13197322
公开号：
US08435987B2
申请日:
2011.08.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula Iwherein A1, A2, B, R1, R2, R4, R5, R6 and Z are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
