COMPOSES PYRAZOLO-PYRIDINONE ET PYRAZOLO-PYRAZINONE SERVANT DE MODULATEURS DE P38, LEUR PROCEDE DE PREPARATION ET LEUR PROCEDE D'UTILISATION PHARMACEUTIQUE
PETTUS, LIPING H.,TASKER, ANDREW,XU, SHIMIN,WURZ, RYAN
申请号：
CA2685597
公开号：
CA2685597C
申请日:
2008.04.24
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have general Formula (I) wherein A1, A2, B, R1, R2, R4, R5, R6 and Z are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula (I).
