Compounds 4 - amino Derivatives of 6 - [methyl (quinoxalin quinolin-1 / IL) - pyrimidin-2-yl) amino] - 5 - carbonitrilo, modulators of PI3K； Pharmaceutical Composition and its use for the treatment of a Selected disease of rheumatoid arthritis, Ankylosing Spondylitis, Osteoarthritis diseases, psoriasis, flammable Atorias or autoimmune.
BUI, MINNA HUE THANH,CUSHING, TIMOTHY D.,GONZALEZ LOPEZ DE TURISO, FELIX,HAO, XIAOLIN,LUCAS, BRIAN
申请号：
CL2014002686
公开号：
CL2014002686A1
申请日:
2014.10.03
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110&delta； activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.COMPUESTOS DERIVADOS DE 4-AMINO-6[METIL(QUINOLIN/QUINOXALIN)-IL)AMINO]PIRIMIDIN-5-CARBONITRILO, MODULADORES DE PI3K； COMPOSICION FARMACEUTICA； Y SU USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD SELECCIONADA DE ARTRITIS REUMATOIDE, ESPONDILITIS ANQUILOSANTE, OSTEOARTRITIS, PSORIASIS, ENFERMEDADES INFLAMATORIAS O AUTOINMUNES.
