The Government of the U.S.A.; as repr. by the Secretary; Dept. of Health & Human Services; the Nat. Inst. of Health
发明人:
Whitehead, Stephen S.,Blaney, Joseph E.,Murphy, Brian R.,Ching-Juh Lai
申请号：
DK12182319
公开号：
DK2589602T3
申请日:
2007.08.15
申请国别(地区):
DK
年份:
2016
代理人:
摘要：
The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3' untranslated region (3'-UTR) comprising a ”30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the ”30 mutation deleted from the 3'-UTR that removes sequence in the 5' direction as far as the 5' boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3'-UTR of a dengue virus of a first serotype with the 3'-UTR of a dengue virus of a second serotype, optionally containing the ”30 mutation and nucleotides additional to the ”30 mutation deleted from the 3'-UTR； and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.
