The present invention relates to a use of earthworm extracts. Particularly, the present invention provides a use of earthworm extracts for preparing a pharmaceutical composition which can enhance the expression of antioxidant genes in brain neurons or inhibit the effects of β-amyloid protein and 1-methyl-4-phenyl-phenylpyridinium on brain neurons. As such, the pharmaceutical composition comprising the earthworm extracts has effects of decreasing the damage of brain neurons.本發明係關於一種地龍蛋白的用途，提供地龍蛋白利用於製造保護腦神經細胞醫藥組成物之用途，藉由該醫藥組成物可提高神經細胞中抗氧化基因之表現，或是抑制β類澱粉質蛋白(β-amyloid protein,Aβ)與1-甲基-4-苯基吡啶離子(1-methyl-4-phenyl-phenylpyridinium,MPP+)對神經細胞的作用，而降低腦神經細胞的損害。
