DAVID ARTHUR BERRY,BRETT ADAM BOGHIGIAN,NATHANIEL W. SILVER,GEOFFREY VON MALTZAHN,RAJEEV CHILLAKURU,MICHAEL J. HAMILL
申请号：
MX2014011614
公开号：
MX2014011614A
申请日:
2013.03.15
申请国别(地区):
MX
年份:
2015
代理人:
摘要：
Nutritive proteins comprising no phenylalanine (Phe) are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein； b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein； and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things. The compositions are useful, for example, to provide protein in the diet of subjects with a disorder characterized by accumulation of Phe in the body.Se proporcionan proteínas nutritivas que no comprenden fenilalanina (Phe). En algunas modalidades, las proteínas nutritivas comprenden al menos uno de un nivel de a) una relación de residuos de aminoácidos de cadena ramificada con respecto al total de residuos de aminoácidos presente en la proteína nutritiva igual o mayor que la relación de los residuos de aminoácidos de cadena ramificada con respecto al total de residuos de aminoácidos presentes en una proteína de referencia； b) una relación de residuos de leucina con respecto al total de residuos de aminoácidos presentes en la proteína nutritiva igual o mayor que la relación de residuos de leucina con respecto al total de residuos de aminoácidos presentes en una proteína de referencia； y c
