An in-vitro skin evaluation device comprisingcultured dermal cells directly attached to a biocompatible reticulated acellular matrixthe matrix prepared from a matrix-forming collagen-containing fluid that is cast, frozen, and dehydrated,the dermal cells providing a cellular lamination layer with cultured epidermal cells directly inoculated and directly attached thereto which establishes a basement membrane between the epidermal cells and the dermal cells.
