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新穎雜環衍生物及其用途
- 专利权人:
- C&C RESEARCH LABORATORIES
- 发明人:
- HO, PIL SU,扈泌秀,YOON, DONG OH,尹东午,尹東午,HAN, SUN YOUNG,韩善荣,韓善榮,LEE, WON IL,李元一,KIM, JUNG SOOK,金贞淑,金貞淑,PARK, WOUL SEONG,朴月成,AHN, SUNG OH,安成梧,KIM, HYE JUNG,金惠贞,金惠貞
- 申请号：
- TW101135774
- 公开号：
- TWI551600B
- 申请日:
- 2012.09.28
- 申请国别(地区):
- TW
- 年份:
- 2016
- 代理人:
- 摘要：
- The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn’s disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.本發明係關於一種新穎雜環化合物，其係適用於製備治療與組織胺4受體之各種不同功能有關疾病之藥物。該藥物尤其適用於治療發炎性疾病、過敏、疼痛、鼻息肉、鼻炎、慢性鼻竇炎、鼻充血、鼻癢、氣喘、慢性阻塞性肺病、類風濕關節炎、異位性皮膚炎、牛皮癬、濕疹、搔癢、皮膚發癢、蕁麻疹、特發性慢性蕁麻疹、硬皮症、結膜炎、角膜結膜炎、眼睛發炎、乾眼症、心臟功能障礙、心律不整、動脈粥樣硬化、多發性硬化、發炎性腸部疾病(包括結腸炎、克隆氏症(Crohn’s disease)、潰瘍性結腸炎)、發炎性疼痛、神經病變性疼痛、骨關節炎疼痛、自體免疫甲狀腺疾病、免疫介導性(亦稱為I型)糖尿病、狼瘡、手術後沾黏、前庭功能損傷與癌症。
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
