The invention provides a new lactic acid bacteria (LAB) strain with immunomodulatory and anti-inflammatory activity and a composition containing and method using the same. The LAB of the invention can be administrated for modulating an immune response in order to restore or prevent metabolic disorders caused by chronic inflammation.本發明提供一種具免疫調節及抗發炎活性之新穎乳酸菌株(LAB)及包含其及使用其之組合物。投予本發明之LAB可調節免疫反應以恢復或預防由慢性發炎引起的代謝疾病。