Provided herein are hydroxypyridone derivatives, for example, a compound of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods for treating, preventing, or ameliorating one or more symptoms of an inflammatory, neurodegenerative, or immune-mediated disease (e.g., multiple sclerosis).本文提供羥吡啶酮衍生物,例如,式I化合物及其醫藥組合物。本文亦提供用於治療、預防、或改善發炎性、神經退化性或免疫媒介疾病(例如,多發性硬化症)之一或多種症狀之方法。