The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.本發明係關於某些二芳基巨環化合物、含有其之醫藥組合物及使用其之方法,包括治療癌症、疼痛、神經疾病、自體免疫疾病及發炎之方法。