Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.本發明闡述作用於蛋白質激酶之化合物及調控蛋白質激酶路徑之方法以及使用該等化合物治療與蛋白質激酶之異常活性有關之疾病及病狀的方法。