The present invention relates to inhibitors of protein kinases of formula I:which can be used in the treatment of various diseases, notably cancer, inflammation or disorders of the central nervous system. It also relates to pharmaceutical compositions containing the compounds according to the invention and their use in therapy.本發明係關於式(I)之蛋白質激酶之抑制劑其可以用於治療多種疾病,特別顯著的是癌症、發炎或中樞神經系統之疾病。本發明也關於含有根據本發明的化合物之醫藥組成物及其在醫療中的用途。