The present invention provides a new group of protein kinase inhibitors, aminopyrimidine derivatives, and pharmaceutically acceptable salts thereof that are useful for treating cell proliferative disease and disorder such as cancer and immune disease. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefore. The invention also provides useful intermediates generated during the syntheses of the aminopyrimidine derivatives.本發明係提供一群新穎之蛋白質激酶抑制劑、胺基嘧啶衍生物，以及其醫藥上可接受之鹽類，其可用於治療細胞增生疾病與病症如癌症與免疫疾病。本發明提供一種合成與投予該蛋白質激酶抑制劑化合物之方法。因此，本發明亦提供一種醫藥配方，包含該蛋白質激酶抑制劑化合物之至少一者，以及醫藥上可接受之載體、稀釋劑或賦形劑。本發明亦提供在合成胺基嘧啶衍生物過程中產生之中間物。
