The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.本發明關於酪胺酸酶抑制劑類、包含該等酪胺酸酶抑制劑之醫藥組成物類、及製備和使用該等酪胺酸酶抑制劑之方法。特定地,本發明包括物質組成物類,其包含至少一種2,4-二羥基苯類似物,該等2,4-二羥基苯類似物抑制酪胺酸酶之活性且抑制黑色素之過度生成。