The present invention relates to a tyrosinase polypeptide inhibitor. The inhibitor is composed of a polypeptide. One or more amino acids of the polypeptide can be further modified through acetylation, amidation, hydroformylation, hydroxylation, lipid modification, methylation, or phosphorylation. The tyrosinase inhibitor of the present invention can be used as a medicinal composition and comprises the above mentioned polypeptide and further comprises a medically acceptable carrier. The medicinal composition of the present invention suppresses the generation of melanin by suppressing the activity of tyrosinase and is applicable to cosmetics, such as whitening agent.本發明係關於一種酪胺酸酶抑制劑,該抑制劑係由一多肽組成。該多肽之一個或多個胺基酸可進一步經過乙醯化、醯胺化、甲醯化、羥基化、脂質修飾、甲基化或磷酸化之修飾。本發明之酪胺酸酶抑制劑可做為醫藥組合物,其係包含上述之多肽,更包含一種醫藥可接受載劑。本發明的醫藥組合物,其係藉由酪胺酸酶之活性抑制進而抑制黑色素之生成,並可應用於化妝品,例如作為美白劑。
