Valzartánt és AHU 377-et tartalmazó trinátrium szupramolekuláris komplex kristályos formái, és az ezekhez tartozó eljárások

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专利权人:

Crystal Pharmatech Co., Ltd.;Suzhou Pengxu Pharmatech Co., Ltd.

发明人:

CHEN, Minhua,ZHANG, Yanfeng,YANG, Chaohui,ZHANG, Xiaoyu,LI, Jiaoyang,WANG, Peng,LI, Pixu

申请号：

HUE15843405

公开号：

HUE043014T2

申请日:

2015.12.08

申请国别(地区):

HU

年份:

2019

代理人:

摘要：

Novel crystalline Form I of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3'-methyl-2'- (pentanoyl {2"-(tetrazol-5-ylate)biphenyl-4'-ylmethyl}amino)butyrate] hydrate, methods for its preparation, pharmaceutical compositions comprising the new form, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.

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http://www.ckcest.cn/home/