CARDONA, FRANCISCO,SOARES DA SILVA, PATRICIO MANUEL VIEIRA ARAUJO,PALMA, PEDRO NUNO LEAL,ROSSI, TINO,BELIAEV, ALEXANDER,KISS, LASZLO ERNO
申请号：
ARP180103525
公开号：
AR114150A1
申请日:
2018.12.03
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
The present application relates to: (a) compound (with R1) of formula (1),R8308A R8310A，(b) A pharmaceutical compound containing such a compound, salt or solution； (c) the use of such a compound, salt or solution in treatment； or (d) Treatments using these compounds, salts or solutions；(e) The process and middlemen related to the synthesis of these compounds. Claim 1: a compound of formula (1) or an acceptable salt or solution on its drug, wherein: R1 is hydrogen, and hydrocarbon c83183331；a. Partially or completely overlapping or bicycle c8332183316c8326c8326；R830808 is hydrogen or c832131/832331；e. R8309es is hydrogen； or r83088 and r83099, together with their attached carbon atoms, form a cyclopentane； r8310es-cooh, CHO o o (ch83222244)； - x, where m is 1, 2 or 3, the rest are ch832222, in the range of - (ch832222) - 8344j8344； - can and can be replaced by another formula (2)；X is hydroxi, alcoxi c83321c 833123；Ciano，n=ch（NHCN）（NH-832222），-Nh-c (pirrolidin-1-il) = NCN, 5 or 6 optional members, replaced by a methyl, phenyl-so83222-r831181 group；-No. 8312； No. 8313；-CO83228R830404，-CH（CO8322；r 830422，-Conr 1ºO-Nr 1ºCor1º83088；Among them, r8311s is c8332183318323；R831222 is hydrogen or c8332131 and 832323；R8313 is hydrogen, and c833213183318324 is selectively replaced with up to three fluorine substitutes or a group of selected substitutes composed of hydrogen, methylene sulfide and cyclopentadiene-c833238331832626；e. Phenyl, 5-6 members of isopropyl and 5-6 substituted members of isopropyl isopropene were used as a substitute for methyl cyclo832383331；a. Isomerization of 5 to 6 members or 5 to 6 members, or alternative isomerization replaced by one or two oxo substitutes； or r831222 and r8313 combine with N atoms to form a non-n-propene group of 5-6 members, which is replaced by a selected methyl and trifluoroethane substitute； e. Hydroxi, hydroximetholo, methoxylo, methylonil, amido, (n, N-dimethyl) tamit and piridilo, O with one or two selected fluoro and oxo rep
