JIE CHENG,DAISUKE FEI - OKA,FANGGUO YE,QINGSHAN TIAN,JIANGQIN SUN,HISASHI MIYAMOTO,SAIMI MAMUTI
申请号：
ARP120103215
公开号：
AR087747A1
申请日:
2012.08.30
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The compound has a strong bactericidal effect and can prevent or treat diarrhea and other intestinal infections related to oral obstruction. Claim 1: a compound represented by a formula, characterized by X being a hydrogen atom or a fluorine atom, R being a hydrogen atom or a tar atom, R1 being (1) cyclopropene, optionally substituted by 1 to 3 halogen atoms or (2) phenyl, optionally substituted by 1 to 3 halogen atoms； R2 is a hydrogen atom；alkyl optionally substituted by 1 or 2 substituents selected from the group consisting of a halogen and hydroxyl atom； alkoxy； haloalkoxy； a halogen atom； cyano； cyclopropyl； nitro； Not me； formyl； alkenyl or alkynyl； or R¹ and R² join to form a 5- or 6-membered ring optionally substituted by alkyl； R³ is (1) a fused heterocyclic group of the formula [2] or [3] where ⁻ ⁻ ⁻ ⁻ ⁻ represents a single bond or a double bond, X¹ is C (R⁵) or N, R⁴ is a hydrogen atom or alkyl, and R⁵ is (a) a hydrogen atom, (b) a halogen atom, (c) cyano, (d) nitro, (e) hydroxy,(f) When X1 is C (r83099), 1 to 3 halogen atoms (g) alquenilo or hydrocarbyl, (H) arilo, or (I) alcox are optionally used to replace the tar of 1 to 3 halogen atoms；R83088 and r83099 are selectively combined to form a ring composed of 5 or 6 members, which is optionally replaced by Oxo. The combined heterocyclic ring group is replaced by 1 or 2 substitutes selected from a group consisting of halogen, cyanogen, nitrogen, hydrogen Xi and tar atoms, and (2) a formula group [4]. X2 is C (r831222) or N, r8310a,R y R son cada uno en forma independiente (a) un tomo de hidr geno (b) un tomo de hal geno (c) ciano (d) nitro (e) amino (f) alquilo sustituido en forma opcional por 1 a 3 sustituyentes a. The tar is selectively replaced by 1 to 3 substitutes selected from the group containing oxy and dimethylamine or champton, or X3 is ch and xi8308es n, R is a hydrogen atom or tar, and is optionally replaced by 1 to 3 substitutes selected from the group consisting of substituted hydroxy and ami
