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Modulators of PDE10
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
STEPHAN BACHMANN,ALEXANDER FLOHR,KATRIN GROEBKE ZBINDEN,MATTHIAS KOERNER,BERND KUHN,JENS PETERS,MARKUS UWE - RUDOLPH
申请号:
ARP120103252
公开号:
AR087771A1
申请日:
2012.09.04
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
1. This table refers to formula (1) compounds as pde10a modulators. These compounds inhibit pde10a and can be used to treat psychosis, such as schizophrenia, panic, Alzheimer's disease, etc. Claim 1: a compound of formula (1), wherein: X and X1 are independent of cr8308o n; ey1 is independent of C or N; Z and Z1 are independent of cr8310;No. 8311,N, O or S; R¹ and R² are independently selected from hydrogen, C₁₋₇ alkyl,C₃₋₈ cycloalkyl,C₁₋₇ haloalkyl,(Alcoxi C) -alquilo Cheterocycloalkyl or C₁₋₇ alkyl optionally substituted by aryl or heteroaryl or R¹ and R²,a. Together with nitrogen atoms, they form a bicyclic ring or isocyclic propyl compound, which can be replaced by 1-3 substitutes independently selected from the tar group of hydroxyl, halogen and c83218331-832727;C₁₋₇ alkoxy,C₁₋₇ haloalkyl and oxo; R³ is hydrogen or C₁₋₇ alkyl;R83088 is hydrogen, c832131 base 832727;C₃₋₈ cycloalkyl,C₁₋₇ haloalkyl or halogen; R⁵ is aryl or heteroaryl, both groups are optionally substituted by C₁₋₇ alkyl,C₃₋₈ cycloalkyl,Halogen, halogen c83217c833127a,C₁₋₇ alkoxy,Hydroxyl group;C₁₋₇ alkoxyalkyl,a. One or two groups of c83218c83318327 tar were used to replace acetyl, cyanogen and nonselective tar;R8310 is hydrogen, halogen, c83218c83318327a matrix;C₃₋₈ cycloalkyl,C₁₋₇ alkoxy,C₁₋₇ haloalkyl,C₁₋₇ alkoxyalkyl,e. Non cyclopentyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyl isopropyltogether with the groups Y¹ and Z to which they are attached, they form an aryl or heteroaryl, both groups are optionally substituted by C₁₋
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