In part, the disclosure relates to systems and methods for applying treatment energy, e.g., electromagnetic radiation such as laser radiation, to body areas having bulges and fat deposits and loose skin. Methods and systems disclosed herein are surprisingly effective in generating a desirable temperature profile in a target region (e.g., moderate hyperthermia in a range of about 42 to about 47° C.)). Such systems and methods also provide a dynamic balance of heating (via the application of optical radiation to the skin surface) and cooling, while substantially confining treatment temperatures to the treatment region (e.g., at or below the dermal-hypodermal (D/H) junction). In some aspects, systems and methods are provided that simultaneously reduce fatty deposits (e.g., through lipolysis) and tighten the skin (e.g., through the increased production of collagen) while minimizing patient discomfort and unintended damage, for example, within the epidermis and hypodermis regions adjacent the treatment region.
