1. Characteristic 1: compound with formula structure (1) or acceptable salt of medicine with formula structure, where x is O, s or CH2； B is natural or unnatural purification or pyridine group； or B is selected from a group of residual formulas (2)；This is N-C (R19) -；Z is n or CH； R1 is h, or other parts of the formula group (3)；R2 is h or other formula (4)；O R1 and R2 are combined into the rest of the formula group (5)；R 3 is C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, C 2-6 alkenyl, C 2-6 alkynyl or C 3-7 cycloalkyl； each of R4, R5, R7 and R8 is independently H, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, halo, -OR20, -SR20 or -N (R20) 2； each of R6, R9, R10, R11 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, 5 or 6 membered monocyclic heteroaryl, 9 or 10 bicyclic heteroaryl members, 4-7 membered heterocycloalkyl, halo, -OR20, -SR20, -S (O) R20, -S (O) 2R20, -S (O) 2N (R20) 2, -NHC (O) OR20, - NHC (O) N (R20) 2, C1-6 haloalkyl, C1-6 hydroxyalkyl, -O- (C1-6 haloalkyl),-Cn, - no, - n (R20) 2, - NH (C1-6 tar) - 5 or 6 list periodic heterosexuals,-NH (C1-6 tar) - (9 or 10 heterocycles)-C (O) R20, -C (O) OR20, -C (O) N (R20) 2 and -NHC (O) R20, wherein said C2-6 alkenyl group and said C2-6 alkynyl group may be optionally substituted with a halo group； Each occurrence of R12 is independently selected from H, - (C1-6 alkylene) -T-R21, - (C1-6 alkylene) m- (C6-10 aryl),-(C1-6 tar) m - (non-n-propyl of 4-7 members)-(C1-6 tar) m - (4-7 members of isopropene)-CH (arilo C6-10) - C (o) or20 and other formulas (6),The rest of C6-10 (C1-6) m (arilo C6-10),said 4 to 7-membered heterocycloalkyl moiety of said group - (C1-6 alkylene) m- (4 to 7-membered heterocycloalkyl) and said 4 to 7-membered heterocycloalkenyl moiety of said group - (C1-6 alkylene) m- ( 4 to 7-membered heterocycloalkenyl) may be optionally substituted with up to three groups, each independently selected from C1-6 alkyl, halo, -OR20, C1-6 haloalkyl, -N (R20)
