MAMMEN, Mathai,HUGHES, Adam,LEE, Tae Weon,HUSFELD, Craig,STANGELAND, Eric,CHEN, Yan,DUNHAM, Sarah
申请号：
ES10173127
公开号：
ES2566155T3
申请日:
2004.02.13
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compounds of formula I: ** Formula ** in which: a is 0 or an integer from 1 to 3； each R1 is independently selected from (C1-4) alkyl, (C2-4) alkenyl, (C2-4) alkynyl, (C3-6) cycloalkyl, cyano, halo, -OR1a, -C (O) OR1b, -SR1c , -S (O) R1d, -S (O) 2R1c and -NR1fR1g； each of R1a, R1b, R1c, R1d, R1e, R1f and R1g is independently hydrogen, (C1-4) alkyl or phenyl (C1-4) alkyl； b is 0 or an integer from 1 to 3； each R2 is independently selected from (C1-4) alkyl, (C2-4) alkenyl, (C2-4) alkynyl, (C3-6) cycloalkyl, cyano, halo, -OR2a, -C (O) OR2b, -SR2c , -S (O) R2d, -S (O) 2R2e and -NR2fR2g. each of R2a, R2b, R2c, R2d, R2e, R3f and R2g is independently hydrogen, (C1-4) alkyl or phenyl (C1-4) alkyl； W is attached at position 3 or 4 with respect to the nitrogen atom in the piperidine ring and represents O or NWa； Wa is hydrogen or (C1-4) alkyl； c is 0 or an integer from 1 to 4； each R3 is independently selected from (C1-4) alkyl, (C2-4) alkenyl, (C2-4) alkynyl, (C3-6) cycloalkyl, cyano, halo, -OR3a, -C (O) OR3b, -SR3c , -S (O) R3d, -S (O) 2R3e and -NR3fR3g； or two R3 groups join to form (C1-3) alkylene, (C2-3) alkenylene or oxyran-2,3-diyl； each of R3a, R3b, R3c, R3d, R3e, R3f and R3g is independently hydrogen or (C1-4) alkyl； R4 is a divalent group of the formula: - (R4a) d- (A1) e- (R4b) fQ- (R4c) g- (A2) h- (R4d) in which d, e, f, g, hei are each independently selected between 0 and 1； R4a, R4b, R4c and R4d are each independently selected from alkylene (C1-10), alkenylene (C2-10) and alkynylene (C2-10), in which each alkylene, alkenylene or alkynylene group is unsubstituted or substituted with 1 to 5 substituents independently selected from (C1-4) alkyl, fluorine, hydroxy, phenyl and phenyl (C1-4) alkyl； A1 and A2 are each independently selected from cycloalkylene (C3-7), arylene (C6-10), -O-arylene (C6-10), arylene (C6-10) -O-, heteroarylene (C2-9), -O-heteroarylene (C2-9), heteroarylene (C2-9) -O- and heterocyclene (C3-6), in which each cycloalkylene is unsubstituted or
