VRUDHULA, Vivekananda M.,PAN, Senliang,RAJAMANI, Ramkumar,NARA, Susheel Jethanand,KARATHOLUVHU, Maheswaran Sivasamban,MAISHAL, Tarun Kumar,DITTA, Jonathan L.,DZIERBA, Carolyn Diane,BRONSON, Joanne J.
申请号：
ES13744927
公开号：
ES2602965T3
申请日:
2013.07.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from hydrogen, C2-C4 alkenyl, C1-C3 alkoxy, C1-C3 alkoxy-C1-C3 alkyl, C1-C3 alkyl, C1-C3 alkylamino, aryl-C1-C3 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C3 alkyl, C1-C3 haloalkyl and C1-C3 hydroxyalkyl； R2 is selected from hydrogen, C1-C3 alkoxy, C1-C3 alkoxycarbonylamino, C1-C3 alkyl, C1-C3 alkylamino, C1-C3 alkylcarbonylamino, amino, arylamino, arylcarbonylamino, C3-C6 cycloalkylamino, C3-cycloalkylaminocarbonylamino C6, halo, C1-C3 haloalkoxy, C1-C3 haloalkyl, C2-C3 haloalkylamino, C2-C3 haloalkylcarbonylamino, hydroxy and C1-C3 phenylalkyl amino, wherein the phenyl is optionally substituted with a C1-C3 alkoxy group； R3 and R4 are independently selected from hydrogen, C1-C4 alkoxy, C1-C3 alkoxy-C1-C3 alkyl, C1-C3 alkoxycarbonyl, C1-C4 alkyl, C1-C3 alkylsulfonyl, aminocarbonyl, cyano, C3-C6 cycloalkyl, di ( C1-C3 alkyl) aminocarbonyl, halo, C1-C3 haloalkoxy, C1-C3 haloalkyl, heteroaryl, hydroxy, C1-C3 hydroxyalkyl and phenyl optionally substituted with a halo group； R5 is C1-C3-Y alkyl or C2-C8 alkyl, wherein C2-C8 alkyl is optionally substituted with one, two, three or four groups independently selected from C1-C3 alkoxy, C1-C3 alkylamino, C1-C3 alkoxy -C2-C3 alkylamino, amino, aryl, di (C1-C3 alkyl) amino, halo, C1-C3 haloalkylamino, C1-C3 haloalkylcarbonylamino, hydroxy, - NRxRy and C3-C8 cycloalkyl, wherein the cycloalkyl is optionally further substituted with one, two or three groups independently selected from C1-C3 alkoxy, C1-C3 alkyl, C1-C3 alkylamino, C1-C3 alkoxy-C2-C3 alkylamino, amino, aryl, aryl-C1-C3 alkyl, halo, C1- haloalkyl C3, C1-C3 haloalkylamino and hydroxy； Rx and Ry, together with the nitrogen atom to which they are attached, form a ring of three to six members； and Y is selected from ** Formula ** in which n is 0, 1, 2 or 3； each R6 is independently selected from hydrogen, C1-C6 alkyl, aryl, aryl-C1-C3 alkyl, C3-C6 cycloalkyl,
