A compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: R1 represents C3-8 alkyl, C3-12 carbocyclyl； C6-12 aryl； C5-12 heteroaryl； phenyl condensed with C3-12 carbocyclyl or phenyl condensed with C3-12 heterocyclyl； wherein any of the C3-12 carbocyclyl and C3-12 heterocyclyl groups mentioned above may be optionally substituted with one or more groups selected from methyl and oxo； and wherein any of the above-mentioned phenyl, C6-12 aryl and heteroaryl groups may be optionally substituted with one or more substituents selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1- haloalkyl 6, -C 1-6 thioalkyl, -SO 2 C 1-4 alkyl, C 1-6 alkoxy, -O-C 3-8 cycloalkyl, C 3-8 cycloalkyl, -SO 2 C 3-8 cycloalkyl, C 3-6 alkenyl, C 3-6 alkynyl 6-oxy-, -C (O) C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, nitro, halogen, cyano, hydroxyl, -C (O) OH, -NH2, -N C1-4 alkyl, -N (C1-4 alkyl) (C1-4 alkyl), -C (O) N (C1-4 alkyl) (C1-4 alkyl), -C (O) NH2, - C (O) NH (C1 alkyl -4), -C (O) C1-6alkyl, -SO4-4alkyl and -SO3-6cycloalkyl； or R1 represents phenyl substituted with phenyl, or phenyl substituted with an optionally substituted monocyclic C5-12 heteroaryl group in which any of the aforementioned monocyclic C5-12 heteroaryl groups may be optionally substituted with one or more groups selected from C1 alkyl -4, halogen and C1-4 alkoxy； A represents in which Y represents a C2-5 alkylene chain, which may be optionally substituted with one or two methyl groups or may be optionally substituted with two alkylene substituents in the same position where the two alkylene substituents are attached to each other. another forming a C3-5 spiro-cycloalkyl group； and B represents H or methyl.Un compuesto de fórmula (I) o una sal farmacéuticamente aceptable, solvato o polimorfo del mismo, incluidos todos los tautómeros y estereoisómeros del mismo, en la que: R1 representa alquilo C3-8, carbociclilo C3-12； arilo C6-12； h
