JOHNS, Brian,VELTHUISEN, Emile,WEATHERHEAD, Jason,SUWANDI, Lita,TEMELKOFF, David
申请号：
ES15742106
公开号：
ES2667793T3
申请日:
2015.07.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula I: ** Formula ** in which: R1 is C1-6 alkyl； R2 is C5-14 aryl, C3-7 cycloalkyl, C3-7 cycloalkenyl, C2-9 heterocycle or C2-9 heteroaryl, wherein each R2 group is optionally substituted with one to four substituents selected from halo, C1-6 alkyl , C1-6 heteroalkyl or C1-6 alkylene or C1-6 heteroalkylene wherein said C1-6 alkylene or C1-6 heteroalkylene are attached to adjacent carbon atoms in said C5-14 aryl, C3-7 cycloalkyl, C3- cycloalkenyl 7, C3-9 heterocycle or C5-9 heteroaryl to form a condensed ring； L is a bond, -CH2 (CO) -, -C1-3 alkylene-, -SO2-, -C (O) -, -C (S) -, -C (NH) -, -C (O) NH -, C (O) NHCH2-, -C (O) N-, - C (O) OCH2-, -C (O) O-, -C (O) C (O) -, -SO2-NH- or -CH2C (O) -； R3 is H, CN, C1-6 alkyl, C5-14 aryl, CH2-C5-14 aryl, CH2- C3-7 cycloalkyl, C3-7 cycloalkyl, C3-7 spirocycloalkyl, C3-7 cycloalkenyl, C2-9 heterocycle or C2-9 heteroaryl, wherein each R3 group is optionally substituted with one to four substituents selected from halo, C1-6 alkyl, C2-8 linked heterocycle, C3-7 cycloalkyl, C1-3 fluoroalkyl, -O-C1 alkyl -6, -C (O) R4, -C (O) NR4, -C (O) NHR4, C5-14 aryl, C1-6 heteroalkyl, -B (OH) 2, C2-9 heterocycle, C1-6 heteroaryl , -C (O) O-C1-6 alkyl, or two substituents attached to adjacent atoms can be joined together to form a condensed ring and that condensed ring may be optionally substituted with R4； R4 is CN, halo, -O-C1-6 alkyl, C1-6 alkyl, C3-7 cycloalkyl, C2-9 heterocycle or C5-14 aryl； and wherein each heterocycle, heteroaryl, heteroalkyl and heteroalkylene comprises one to three heteroatoms selected from S, N, B or O.Un compuesto de Fórmula I:**Fórmula** en la que: R1 es alquilo C1-6； R2 es arilo C5-14, cicloalquilo C3-7, cicloalquenilo C3-7, heterociclo C2-9 o heteroarilo C2-9, en la que cada grupo R2 está opcionalmente sustituido con de uno a cuatro sustituyentes seleccionados entre halo, alquilo C1-6, heteroalquilo C1-6 o alquileno C1-6 o heteroalquileno C1-6 en la que dicho alquileno C1-6 o heteroalquileno C1-6
