GAJ JUNKHUA,ГАЙ Юнхуа,OR JAT SUN,ОР Ят Сунь,VAN CHZHEH,ВАН Чжэ
申请号：
RU2010123928/04
公开号：
RU0002493160C2
申请日:
2008.11.14
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula I , where A is -(C=O) L201 is absent M is absent or is selected from O or NR1 where R1 is selected, during each appearance thereof, from hydrogen L101 is selected from -C1-C8 alkylene, -C2-C8 alkenylene or C1-C8 alkylene-O or -C1-C8 alkylene, -C2-C8 alkenylene or C1-C8 alkylene-O, each of which is independently substituted with 1, 2 or 3 substitutes selected from C1-C8 alkyl or halogen, or two hydrogen atoms per carbon atom of -C1-C8 alkylene, -C2-C8 alkenylene or C1-C8 alkylene-O can be substituted with substitutes, where two substitutes, taken together, form a C3-C12 cycloalkyl ring Z101 is phenyl phenyl substituted with 1, 2 or 3 halogens or thienyl W101 is absent X and Y, taken together with carbon atoms with which they are bonded, form a phenyl ring R is -C1-C8 alkyl R is -C1-C8 alkyl, -C2-C8 alkenyl or CHQ1Q2 Q1 and Q2 each is independently F, Cl or Br G is selected from -OH or -NHS(O)2-R2 R2 is - C3-C12 cycloalkyl m is 1 m is 1 and s is 1. The invention also relates to a pharmaceutical composition which inhibits serine protease activity, particularly activity of hepatitis C virus (HCV) NS3-NS4A protease, based on said compounds.EFFECT: obtaining novel compounds and a pharmaceutical composition based on said compounds, which can be used in medicine for treating hepatitis C.19 cl, 4 dwg, 3 tbl, 1588 exИзобретение относится к соединениям формулы Iгде A является -(C=O) L201 отсутствует M отсутствует или его выбирают из O или NR1 где R1 выбирают при каждом его появлении из водорода L101 выбирают из -C1-C8 алкилена, -C2-C8 алкенилена или C1-C8 алкилен-O или -C1-C8 алкилена, -C2-C8 алкенилена или C1-C8 алкилен-O, каждый из которых замещен независимо 1, 2 или 3 заместителями, выбранными из C1-C8 алкила или галогена, или два атома водорода на атоме углерода -C1-C8 алкилена, -C2-C8 алкенилена или C1-C8 алкилен-O могут быть заменены заместителями, где два заместителя, взятые вместе, образуют C3-C12 ц
