AMANS, Dominique,BAMBOROUGH, Paul,BARKER, Michael David,BIT, Rino Antonio,BROWN, John Alexander,CAMPBELL, Matthew,GARTON, Neil Stuart,LINDON, Matthew J,SHIPLEY, Tracy Jane,THEODOULOU, Natalie Hope,WEL
申请号：
ES14709932
公开号：
ES2654362T3
申请日:
2014.03.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I): ** (See formula) ** where: V is N or C-R2 W is N or C-R8； X is N, CH, or C (CH3)； Y is N or C-R5； Z is N or C-R15； Q is N or CH； R1 is C1-4alkyl or deuterated C1-4alkyl； R2, when present, is H, OH, C1-4 alkyl, halo, -CF3, -NH2, -O C1-4alkyl, -NHC (O) H, -NHC (O) C1-4 alkyl, -N ( CH3) C (O) C1-4 alkyl, -NHC (O) NH2, -NHC (O) C1-4NH2 alkylene, -N (CH3) C (O) NH2, -N (CH3) C (O) C1 alkylene - 4NH2, -NHalkylene C2-4OCH3, -N (CH3) alkylene C2-4OCH3, -Oalkylene C2-4OCH3, -Oalkylene C2-4OH or R2 is a group selected from -G-CH2CH (R3) (R4), -G -CH (R3) (R4) and -G-R3 where G is NH, N (CH3), O, C (O) NH or NHC (O)； R3 is phenyl, pyridinyl, C3-7 cycloalkyl or a heterocycle optionally substituted with>； = O； and R4 is H or C1-4 alkyl； R5, when present, is H, C1-4 alkyl, halo, -CF3, CN, OH, -O C1-4alkyl, -CH2NH2, -OCF3, -SO2CH3, - C (O) NH1-4alkyl or -CO2H ；Un compuesto de fórmula (I): **(Ver fórmula)** en la que: V es N o C-R2 W es N o C-R8； X es N, CH o C(CH3)； Y es N o C-R5； Z es N o C-R15； Q es N o CH； R1 es alquilo C1-4 o alquilo C1-4 deuterado； R2, cuando está presente, es H, OH, alquilo C1-4, halo, -CF3, -NH2, -Oalquilo C1-4, -NHC(O)H, -NHC(O)alquilo C1- 4, -N(CH3)C(O)alquilo C1-4, -NHC(O)NH2, -NHC(O)alquilen C1-4NH2, -N(CH3)C(O)NH2, -N(CH3)C(O)alquilen C1- 4NH2, -NHalquilen C2-4OCH3, -N(CH3)alquilen C2-4OCH3, -Oalquilen C2-4OCH3, -Oalquilen C2-4OH o R2 es un grupo seleccionado entre -G-CH2CH(R3)(R4), -G-CH(R3)(R4) y -G-R3 en los que G es NH, N(CH3), O, C(O)NH o NHC(O)； R3 es fenilo, piridinilo, cicloalquilo C3-7 o un heterociclo opcionalmente sustituido con >；=O； y R4 es H o alquilo C1-4； R5, cuando está presente, es H, alquilo C1-4, halo, -CF3, CN, OH, -Oalquilo C1-4, -CH2NH2, -OCF3, -SO2CH3, - C(O)NHalquilo C1-4 o -CO2H；
