ALLEGRETTI, PAUL,CHOI, SEOK-KI,GENDRON, ROLAND,FATHEREE, PAUL R.,JENDZA, KEITH,MCKINNELL, ROBERT MURRAY,MCMURTRIE, DARREN,OLSON, BROOKE
申请号：
ES08743204
公开号：
ES2529745T3
申请日:
2008.04.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I: ** Formula ** in which: r is 1； Ar is selected from: ** Formula ** R1 is selected from -COOR1a, -NHSO2R1b, -SO2NHR1d, -SO2OH, -C (O) NH- SO2R1c, -P (O) (OH) 2, -CN, -OCH (R1e) -COOH, tetrazol-5-yl, ** Formula ** R1a is H, -C1-6alkyl, -C1-3alkylenearyl, -C1-3alkyleneheteroaryl, -C3-7cycloalkyl, -CH (C1-alkyl -4) OC (O) R1aa, -C0-6 alkyleneomorpholine, ** Formula ** R1aa is -O-C1-6 alkyl, -O-C3-7 cycloalkyl, -NR1abR1ac or -CH (NH2) CH2COOCH3； R1ab and R1ac are independently selected from H, -C 1-6 alkyl and benzyl, or taken together as - (CH2) 3-6-； R1b is R1c or -NHC (O) R1c； R1c is -C1-6 alkyl, -C0-6-O-R1ca alkylene, -C1-5-NR1cbR1cc alkylene, C0-4 -alkylenearyl or C0-4 -alkyleneheteroaryl； R 1ca is H, -C 1-6 alkyl or -C 1-6 alkylene-O-C 1-6 alkyl； R1cb and R1cc are independently selected from H and -C1-6 alkyl, or taken together as - (CH2) 2-O- (CH2) 2- or - (CH2) 2-N [C (O) CH3] - ( CH2) 2-； R1d is H, R1c, -C (O) R1c, or -C (O) NHR1c； R1e is -C 1-4 alkyl or aryl； Y is -C (R3) -, Z is -N-, Q is -C (R2) - and W is a bond； Y is -N-, Z is -C (R3) -, Q is -C (R2) - and W is a bond； Y is -C (R3) -, Z is -N-, Q is -N- and W is a bond； or Y is -C (R3) -, Z is -CH-, Q is -C (R2) - and W is -C (O) -； R2 is selected from H, halo, -NO2, -C1-6alkyl, -C2-6alkenyl, -C3-6cycloalkyl, -CN, -C (O) R2a, -C0-5-OR2b alkylene, -C0 alkylene -5-NR2cR2d, -C0-3 -alkylenearyl and -C0-3 -alkylene-heteroaryl； where R2a is selected from H, -C1-6 alkyl, -C3-6 cycloalkyl, -OR2b and -NR2cR2d； R2b is selected from H, -C1-6alkyl, -C3-6cycloalkyl and -C0-1 -alkylenearyl； and R2c and R2d are independently selected from H, -C1-4alkyl and -C0-1alkylenearyl； R3 is selected from -C1-10 alkyl, -C2-10 alkenyl, -C3-10 alkynyl, -C0-3 alkylene-C3-7 cycloalkyl, -C2-3 alkenylene-C3-7 cycloalkyl, -C2-3-alkylene C3-7 cycloalkyl, -C0-5-NR3a-C0-5-R36 alkylene, -C0-5-O30 alkylene C0-5-R3b alkylene, -C0-5-S-C1-5-R3b alkylene and - C0-3 alkylenearyl； where R3a is selected from H, - C1-6 alkyl, -
