ALLEGRETTI Pol (US),АЛЛЕГРЕТТИ Пол (US),ChOI Seok-ki (US),ЧОИ Сеок-ки (US),GENDRON Roland (US),ГЕНДРОН Роланд (US),FAZERI Pol R. (US),ФАЗЕРИ Пол Р. (US),DZhENDZA Kit (US),ДЖЕНДЗА Кит (US),MAKKINNELL R,ALLEGRETTI POL,АЛЛЕГРЕТТИ Пол,CHOI SEOK-KI,ЧОИ Сеок-ки,GENDRON ROLAND,ГЕНДРОН Роланд,FAZERI POL R.,ФАЗЕРИ Пол Р.,DZHENDZA KIT,ДЖЕНДЗА Кит,MAKKINNELL ROBERT MJURREJ,МАККИННЕЛЛ Роберт Мюррей,MAKMERTRI D
申请号：
RU2009143362/04
公开号：
RU0002476427C2
申请日:
2008.04.23
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to new compounds of formula (I) and to their pharmaceutically acceptable salts wherein r represents 1； Ar is specified in and , R1 is specified in -COOR1a, -NHSO2R1b, -SO2NHR1d, -SO2OH, -O-CH(R1e)-COOH and tetrazol-5-yl, R1a represents H, -C1-6alkyl, -C1-3alkylenaryl, -C1-3alkyleneheteroaryl, - C3-7cycloalkyl, -CH(C1-4alkyl)OC(O)R1aa, or R1aa represents -O-C1-6alkyl or -O-C3-7cycloalkyl； R1b represents R1c； R1d represents -C1-6alkyl or -C0-4alkylenaryl； R1d represents -C(O)R1c or -C(O)NHR1c； R1e represents -C1-4alkyl； Y represents -C(R3)-, Z represents -N-, Q represents -C(R2)-, and W represents a bond； Y represents -N-, Z represents -C(R3)-, Q represents -C(R2)-, and W represents a bond； Y represents -C(R3)-, Z represents -N-, Q represents -N-, and W represents a bond； or Y represents -C(R3)-, Z represents -CH-, Q represents -C(R2)-, and W represents -C(O)-； R2 is specified in H, halogen, -C1-6alkyl, -C3-6dicloalkyl, and -C0-5alkylene-OR2b； wherein R2b is specified in H and -C1-6alkyl； R3 is specified in -C1-10alkyl and -C0-5alkylene-O-C0-5alkylene-R3b； and R3b represents -C1-6alkyl； X represents -C1-12alkylene-, where at least one group -CH2- in alkylene is substituted by the group -NR4a-C(O)- or -C(O)-NR4a-, wherein R4a is specified in H, -OH, and -C1-4aalkyl； R5 is specified in -C0-3 alkylene-SR5a, -C0-3alkylene-C(O)NR5bR5c, -C0-3alkylene-NR5b-C(O)R5d, -NH-C0-1alkylene-P(O)(OR5e)2, -C0-2alkylene-CHR5g-COOH and -C0-3alkylene-C(O)NR5h-CHR5i-COOH； R5a represents H or -C(O)-R5aa； R5aa represents -C1-6alkyl, -C0-6alkylene-C3-7cycoalkyl, -C0-6alkylenaryl, or -C0-6alkylenemorpholine； R5b represents -OH, -OC(O)R5ba, -CH2COOH or -OC(S)NR5bbR5bc； R5ba represents -C1-6alkyl, -OCH2-aryl or -CH2O-aryl； R5bb and R5bc independently represents -C1-4alkyl； R5c represents H； R5d represents H； R5e represents H； R5g represents H or -CH2-O-(CH2)2-O-CH3； R5h represents H； R5i represents -C0-3alkylenaryl； R6 is speci
