KALLUS, CHRISTOPHER,BROENSTRUP, MARK,EVERS, ANDREAS,GLOBISCH, ANJA,SCHREUDER, HERMAN,WAGNER, MICHAEL
申请号：
ES09757185
公开号：
ES2494390T3
申请日:
2009.05.22
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of the formula I ** Formula ** and / or a stereoisomeric form of the compound of the formula I and / or mixtures of these forms in any proportion, and / or a physiologically tolerated salt of the compound of the formula I, in which X represents -C (O) - or -SO2-, U represents an oxygen atom, a sulfur atom, NH, -C (O) -NH- or -alkylene (C0-C4) -, A represents an atom of oxygen, a sulfur atom, NH, -C (O) -NH- -NH-C (O) - -NR2- or -alkylene (C0-C4) -, V represents 1) -alkylene (C2-C9) - , where alkylene is unsubstituted or independently substituted in each case once, twice or three times with -OH, NH2 or halogen, 3) -C1-C2-alkylene-C3-C6-alkyl-(C1-C2) alkylene -, where the cycloalkyl is independently substituted in each case once, twice or three times with R15, or 3) -alkylene (C3-C9) -, D represents -alkylene (C1-C2) -, Y represents 1) a covalent bond , 2) -C3-C12 cycloalkyl, where the cycloalkyl is independently substituted in each case once, twice or three times with R15, 3) -aryl (C6-C14), where the aryl is unsubstituted or independently substituted in each case once, twice or three times with R15, or 4) Het, where Het refers to a 4 to 15-membered heterocyclic ring system that has 4 to 15 ring atoms that are present in one, two or three ring systems that are connected to each other, and that comprise, depending on the size of the ring, one, two, three or four heteroatoms the same or different from the oxygen, nitrogen or sulfur series, and where Het is unsubstituted or independently substituted in each case once, twice or three times with a (C1-C3) alkyl, halogen, -NH2 , -CF3 or -O-CF3, R1 represents 1) a hydrogen atom, 2) -alkyl (C1-C6) -, 3) -alkyl (C1-C6) -OH, 4) -alkyl (C0-C4) - (C3-C6) cycloalkyl -, 5) - (C1-C10) alkyl -OC (O) -O-R2, 6) - (CH2) r-aryl (C6-C14), where the aryl is unsubstituted or independently substituted in each case once, twice or three times with R15, and r is the integer zero, 1, 2 or 3, or 7) - (CH2) s-Het, where Het refers to a 4
