JONES, LYN HOWARD,MOWBRAY, CHARLES ERIC,PRICE, DAVIS ANTHONY,SELBY, MATTHEW DUNCAN,STUPPLE, PAUL ANTHONY
申请号：
ES06126433
公开号：
ES2385659T3
申请日:
2002.04.04
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of the formula (I) ** Formula ** or its pharmaceutically acceptable salt or solvate, wherein: either R1 is H, C1-C6 alkyl, C3-C7 cycloalkyl or -OR7, said C1-C6 alkyl and cycloalkyl being C3-C7 optionally substituted with halo, -CN, -OR10, S (O) xR1 °, -CO2R10, -CONR5R10, -OCONR5R10, -NR5CO2R10, -NR10R11, -NR5COR10, -SO2NR5R10, -NR5CONR5R2； and R2 is H, C1-C6 alkyl, C3-C6 alkenyl or R9, said C1-C6 alkyl being optionally substituted with halo, -OR5, -OR12, -CN, -CO2R7, -OCONR5R5, -CONR5R5, -C (>； = NR5) NR5OR5, -CONR5NR5R5, -NR6R8, -NR5R12, -NR5COR5, -NR5COR8, -NR5COR12, -NR5CO2R5, -NR5CONR5R5, -SO2NR5R5, -NR5SO2R5, R8, R8 or R, R8, R8, R8, R8, R8, R8, R8, R8, R8, R8 or R5, R8, R8, R8, R8, R8, R8, R8 and R8 unbranched C3-C4 alkylene, optionally substituted with oxo, where a methylene group of said C3-C4 alkylene is replaced with an oxygen atom or a nitrogen atom, said nitrogen atom being optionally substituted with R10； R3 is H or alkyl C1-C6, said C1-C6 alkyl being optionally substituted with halo, -CN, -OR5, -CO2R5, -CONR5R5, -OCONR5R5, -NR5CO2R5, -NR6R6, -NR5COR5, -SO2NR5R5, -NR5CONR5R2, -NR5R5R5, -NR5R5SO2 R9； R4 is phenyl optionally substituted with R8, halo, -CN, C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl, C1-C6 alkoxy, -CONR5R5, OR13, SoxR6, O- (C1-C6 alkylene) -CONR5R5, O- (C1-C6 rent) -NR5R5 or O- (C1 rent -C6) -OR6； onaphthyl； each R5 is independently either H, C1-C6 alkyl or C3-C7 cycloalkyl or, when two R5 groups are attached to the same nitrogen atom, those two groups taken together with the nitrogen atom to which they are attached, represent azetidyl, pyrrolidine, piperidinyl, homopiperidinyl, piperazinyl, homopiperazinyl or morpholinyl. being azetidinyl, pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl, homopiperazinyl and morpholinyl optionally substituted with C1-C6 alkyl or C3-C7 cycloalkyl； each R6 is independently either H, C1-C6 alkyl or C3-C7 alkyl； R7.es C6 or C3-C7 cycloalkyl； R8 is a five or six membered aromatic hetero
