18-METHYL-19-NOR-ANDROST-4-EN-17,17-SPIROETHER(18-METHYL-19-NOR-20-SPI ROX-4-EN-3-ONE) ET COMPOSITIONS PHARMACEUTIQUES COMPRENANT LEDIT COMPOSE

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专利权人:

BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

发明人:

BOHLMANN, ROLF,KUHNKE, JOACHIM,HUEBNER, JAN,GALLUS, NORBERT,MENGES, FREDERIK,BORDEN, STEFFEN,MUHN, HANS-PETER,PRELLE, KATJA

申请号：

CA2656443

公开号：

CA2656443C

申请日:

2007.06.29

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The invention relates to novel 18-methyl-19-nor-androst-4-en-17,17- spiroether of general formula (I), where Z = O, two H, =NOR or =NNHSO2R, R = H, or straight or branched chain C1-4 or C3-4alkyl, R4 = H, halogen, or CF3 and R6 and/or R7 are .alpha.- or ß-positioned and R6 and R7 independently = H or straight or branched chain C1-4 or C3-4alkyl or a straight or branched chain C2-4 or C3-4alkylene or a saturated C3-5 cycloalkyl, or together form a methylene group or a double bond. The novel compounds have gestagenic and antimineralcorticoid action.

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