JOUBERT, ELIZABETH,FEY, STEPHEN JOHN,LOUW, JOHAN,ULVEN, TROND,TYAGI, RAHUL
申请号：
ES10771690
公开号：
ES2526660T3
申请日:
2010.10.07
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of formula I or a physiologically acceptable salt thereof: Formula ** ** wherein Ar is benzene n is 1 R1, R2, R3 and R4 are selected, independently, from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, aryl, C1-6 alkyl, C2-6 alkynyl, C2-6 alkenyl, C3-10 , C3-10 cycloalkyl-C1-3 alkyl, C5-10 cycloalkenyl, C5-10 cycloalkenyl-C1-3alkyl, C1-4alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, aminocarbonyl, C1-4 alkylaminocarbonyl, di- (C1-3 alkyl) aminocarbonyl, pyrrolidin-1-ylcarbonyl, piperidin-1- ylcarbonyl, morpholin-4-ylcarbonyl, piperazin-1-ylcarbonyl, 4- (C1-4 alkyl) piperizin-1-ylcarbonyl, C1-4 alkoxycarbonyl, amino, alkylamino C1-4 alkylamino, di- (1-3C) alkylamino, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, 4- (C1-4alkyl) piperazin-1- yl, C1-4alkylcarbonylamino, C1-6alkyloxy, C3-10 cycloalkyloxy, C5-10 cycloalkenyloxy, aryloxy, C1-4 alkylsulfanyl, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, cycloalkylsulfanyl C3-10, C3-10 cycloalkylsulfinyl, cycloalkylsulfonyl C3-10, cicloalquenilsulfa nile C5-10, C5-10 cycloalkenylsulfinyl, C5-10 cycloalkenylsulfonyl, arylsulfanyl, arylsulfinyl, arylsulfonyl, hydroxy, cyano and nitro, X1 is selected, independently, from the group consisting of -OH, -CH2OR5, H, -OR5 and -C (O) R5 X2 is selected from the group consisting of -OH, -CH2OR5, H, -OR5, and -C (O) R520 X3 is -O- X4 is -O- X5> = (CH2) m- m is 0, 1, 2 or 3. A is selected from the group consisting of -CO2H, -CO2R5, -SO3H -SO2HNR5 -PO (OH) 2 -CONH (CO) R5 -CONH (CO) H, -CONHSO2R5 -CONHCN and ** ** Formula where the bond marked * is attached to ethylene and R5 is selected from the group consisting of alkyl chain straight or branched C1-C6 alkyl, C2-C6 chain straight or branched, or alkynyl, aryl, aralkyl, heteroaryl, carbocycle and heterocycle with the proviso that: * X2 is different from -OH, when X3 is -O- and at least one X1 is OH * If R1, R2, R3 and R4 are -H, A is not -CO2H or -CO2R5, when X1 is -OH, X3 and X4 are -O-, X2
