МУНЦЕРТ Герд (DE),ШТЕГМАЙЕР Мартин (DE),БАУМ Анке (AT)
申请号：
RU2010136326/15
公开号：
RU2010136326A
申请日:
2010.09.01
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A pharmaceutical composition comprising effective amounts:! (i) compounds of formula (I)! ! in which R1, R2, which may be the same or different, are hydrogen or optionally substituted C1-C6 alkyl, or! R1 and R2 together represent a 2- to 5-membered alkyl bridge, which may contain 1-2 heteroatoms,! R3 is hydrogen or a group selected from the group consisting of optionally substituted C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl and C6-C14 aryl, or! a group selected from the group consisting of optionally substituted and / or bridged C3-C12 cycloalkyl, C3-C12 cycloalkenyl, C7-C12 polycycloalkyl, C7-C12 polycycloalkenyl, C5-C12 spirocycloalkyl, C3-C12 heterocycloalkyl contains 1-2 heteroatoms, and C3-C12-heterocycloalkenyl, which contains 1-2 heteroatoms, or! R1 and R3 or R2 and R3 together represent a saturated or unsaturated C3-C4 alkyl bridge which may contain 1 heteroatom,! R4 is a group selected from the group consisting of hydrogen, —CN, hydroxy, —NR6R7 and halogen, or! a group selected from the group consisting of optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C5 alkyloxy group, C2-C5 alkenyloxy group, C2-C5 alkynyloxy group, C1-C6 alkylthio group , C1-C6-alkylsulfoxyl group and C1-C6-alkylsulfonyl,! L is a connecting moiety selected from the group consisting of optionally substituted C2-C10-alkyl, C2-C10-alkenyl, C6-C14-aryl, -C2-C4-alkyl-C6-C14-aryl, -C6-C14-aryl- C1-C4 alkyl, optionally bridging C3-C12 cycloalkyl and heteroaryl, which contains 1 or 2 nitrogen atoms,! n is 0 or 1,! m is 1 or 2,! R5 is a group selected from the group consisting of optionally substituted morpholinyl, n1. Фармацевтическая композиция, включающая эффективные количества: ! (i) соединения формулы (I) ! ! в которой R1, R2, которые могут быть одинаковыми или разными, обозначают водород или необязательно замещенный C1-С6-алкил, или ! R1 и R2 совместно обозначают 2- - 5-членный алкильный мостик, который может содержать 1-2 гетероатома, ! R3 обозначает во
