KUNTTS Kevin Uejn (US),КУНТЦ Кевин Уэйн (US),CHESUORT Richard (US),ЧЕСУОРТ Ричард (US),DUNKAN Kennet Uillyam (US),ДУНКАН Кеннет Уилльям (US),KAJLKHAK Khajke (US),КАЙЛЬХАК Хайке (US),VARKHOLIK Natali (,KUNTTS Kevin Uejn,КУНТЦ Кевин Уэйн,CHESUORT Richard,ЧЕСУОРТ Ричард,DUNKAN Kennet Uillyam,ДУНКАН Кеннет Уилльям,KAJLKHAK Khajke,КАЙЛЬХАК Хайке,VARKHOLIK Natali,ВАРХОЛИК Натали,KLAUS Kristin,КЛАУС Крист
申请号：
RU2013150345
公开号：
RU0002632193C2
申请日:
2012.04.13
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: invention relates to compounds of formula : , wherein X1 is N or CR11； X2 is N or CR13； Z is NR7R8 or CR7R8R14； Each of R1, R5, R9 and R10 is independently H or C1-C6 alkyl optionally substituted with one or more substituents selected from the group consisting of halogen and hydroxyl； Each of R2, R3 and R4 is independently -Q1-T1, wherein Q1 is a bond or a C1-C3 alkyl linker optionally substituted with halogen and T1 is H, halogen, hydroxyl or RS1, wherein RS1 is C1-C3 alkyl, C3-C8 cycloalkyl and RS1 is optionally substituted with one or more substituents selected from the group consisting of halogen and hydroxyl； R6 is C6-C10 aryl or a 5- or 6-membered heteroaryl containing 1 or 2 heteroatoms independently selected from N, O and S, each of which is optionally substituted with one or more -Q2-T2, wherein Q2 is a bond or C1 -C3 alkyl linker optionally substituted with halogen, and T2 is H, halogen, -NRaRb or RS2, wherein each of Ra and Rb is independently H or RS3, each of RS2 and RS3 is independently C1-C6alkyl, or 4-12 Membered heterocycloalkyl having 1 or 2 heteroatoms independently selected from N and O or Ra and Rb form together with N atom, to which they are attached, 4-12 membered heterocycloalkyl ring containing the heteroatom N and optionally containing 0 or 1 additional heteroatom selected from N or O； R7 is -Q4-T4 wherein Q4 is a bond or a C1-C4 alkyl linker optionally substituted with halogen and T4 is H or RS4 wherein each RS4 is C1-C6 alkyl, C3-C8 cycloalkyl or 4-12 membered heterocycloalkyl Containing one heteroatom selected from O or N and each of RS4 is optionally substituted with one or more -Q5-T5, wherein Q5 is a bond and T5 is H, halogen, C1-C6 alkyl, amino or mono-C1-C6alkylamino； Each of R8, R11, R12 and R13 is independently H, halogen, hydroxyl or RS6, wherein RS6 is C1-C6 alkyl or C3-C8 cycloalkyl, a 4- to 12-membered heterocycloalkyl containing 1 or 2 heteroatoms； or R7 and R8 form together with the N atom to w
