A compound having the structure of Formula I: ** Formula ** or a physiologically acceptable salt thereof, wherein X1, X2, X3, X4, X5, X6, X7 and X8 are independently CR4 or N； Y1 is hydrogen or -C (R4) 3, and each R4 is the same or different； Y2 and Y3 are independently hydrogen, halogen, or -C (R3) 3, and each R3 is the same or different； R1 is selected from hydrogen, halogen, C1-6 alkyl, quinolinyl, ** Formula **, C6-30 aryl, a 3-6 membered heterocycloalkyl containing 1-2 heteroatoms selected from N, O, and S, and heteroaryl from 5- or 6-membered containing 1-4 heteroatoms selected from N, O, and S, in which each quinolinyl, ** Formula **, C6-30 aryl, 3-6 membered heterocycloalkyl, and 5- or 6 membered heteroaryl can be optionally substituted with one or two the same or different R4； R2 is selected from halogen, C1-6 alkyl, quinolinyl, ** Formula **, C6-30 aryl, 3-6 membered heterocycloalkyl containing 1-2 heteroatoms selected from N, O, and S, and 5- or 6-heteroaryl members containing 1-4 heteroatoms selected from N, O, and S, wherein each quinolinyl, ** Formula **, C6-30 aryl, 3-6 membered heterocycloalkyl, and 5- or 6 membered heteroaryl may be optionally substituted with one or two R4 the same or different； each R3 is independently selected from hydrogen, halogen, cyano, C1-6alkyl, and C1-6alkoxy, wherein each of the C1-6alkyl and C1-6alkoxy may optionally be substituted with halogen, amino, hydroxyl, C1-6 alkoxy or cyano； each R4 is independently selected from hydrogen, halogen, cyano, C1-6 alkoxy, -S (O) 2R5, -C (O) OR5, -C (O) R5, -C (O) NR6R7, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each of C1-6 alkoxy, -S (O) 2R5, -C (O) OR5, - C (O) R5, -C (O) NR6R7, alkyl C1-6, C2-6 alkenyl and C2-6 alkynyl can be optionally substituted with halogen, amino, hydroxyl, C1-6 alkoxy or cyano； R5, R6 and R7 are independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, wherein each of C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl may be optionally substi
