KLEIN MICHEL ROBERT,LIN MIN YONG,VAN MEIJGAARDEN KRISTA ELISABETH,FRANKEN CORNELUS LEONARDUS MARIA COLETA,LEYTEN ELIANE MADELEINE SOPHIE,OTTENHOF TOM HENRICUS MARIA
申请号：
IN4325/CHENP/2007
公开号：
IN282828B
申请日:
2007.10.01
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The invention identifies a narrow subset of Mycobacterium latency associated antigens and/or epitopes that are capable of eliciting an immune response in vivo and and in vitro in a mammal. The invention provides methods and compositions for detection and immunization against latent Mycobacterium infections. These compositions comprise those Mycobacterial latency antigens that are actually capable of eliciting an immune response in vivot in mammals experiencing a latent Mycobacterium infection. More preferably the compositions comprise those antigens that are preferentially recognized by latently infected individuals and which antigens are not, or to a much lesser extent, recognized in individuals having an active Mycobacterium infection or in individuals having Mycobacterium induced symptoms or diseases, such as in patients infected with M. tuberculosis suffering from tuberculosis disease (TB).
