compound, composition, pharmaceutically acceptable salt of a compound, combination, pharmaceutical formulation, methods for killing a mycobacterium and / or inhibiting replication of disease causing mycobacteria in an animal, for treating a mycobacterial infection in an animal and for treating a disease resulting from a mycobacterial infection of a mammal, and use of a compound.
CARLOS ALEMPARTE-GALLARDO,DAVID BARROS-AGUIRRE,ILARIA GIORDANO,JACOB J. PLATTNER,M.R.K. (DICKON) ALLEY,VINCENT HERNANDEZ,XIANFENG LI
申请号：
BR112017017211
公开号：
BR112017017211A2
申请日:
2016.02.12
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
substituted benzoxaborols whose structures comprise formula (iii), wherein r3 is selected from -ch3, -ch2ch3, -ch2 = ch2, -ch2ch2ch3, -ch (ch3) 2, -ch2ch2 = ch2 and cyclopropyl each R1 and R2 are independently selected from h, -ch3, -ch2ch3, -ch2ch2ch3 and -ch (ch3) 2； compositions containing such compounds for their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds.benzoxaboróis substituídos cujas estruturas compreendem a fórmula (iii), em que r3 é selecionado a partir de -ch3, -ch2ch3, -ch2=ch2, -ch2ch2ch3, -ch(ch3)2, -ch2ch2=ch2 e ciclopropila, cada um de r1 e r2 são independentemente selecionados de h, -ch3, -ch2ch3, -ch2ch2ch3 e -ch(ch3)2； composições contendo tais compostos, a seu uso em terapia, incluindo seu uso como agentes anti-micobacterianos, por exemplo no tratamento de uma infecção por micobactéria em um mamífero, e métodos para a preparação de tais compostos.
