William R. Jacobs, Jr.,Kari Sweeney,Dee Dao,Steven A. Porcelli,John Chan,Tsungda Hsu
申请号：
US12450193
公开号：
US08591918B2
申请日:
2008.03.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided are mycobacteria deleted in at least a portion of a region 3 ESAT-6-like gene cluster. Also provided are mycobacteria comprising a mutation in an roc-1 gene. Additionally, vaccines comprising these mycobacteria are provided. Further provided are methods of making a recombinant mycobacterium, methods of inducing an immune response in a mammal, methods of inhibiting IL-12 production in a mammal, and methods of stimulating IL-12 production in a mammal. Vaccine adjuvants are also provided, as are methods of inducing immunity to a target antigen in a mammal.
