KOŁACZKOWSKI, Marcin,MARCINKOWSKA, Monika,BUCKI, Adam,ŁYSAKOWSKI, Tomasz,PAWŁOWSKI, Maciej
申请号：
IBIB2013/052204
公开号：
WO2013/140347A1
申请日:
2013.03.20
申请国别(地区):
IB
年份:
2013
代理人:
摘要：
Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted；or 9-or 10-membered bicyclic group, linked to –(O) x - (CH 2 ) y -through one of its aromatic carbon atoms,consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5-or 6-membered non-aromaticheterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C1 -C3 - alkyls； D represents a group selected from:phenyl unsubstituted or substituted； naphthyl unsubstituted or substituted；thiophene unsubstituted or substituted；bicyclic group consisting of imidazolering fused with5-membered non-aromatic carbocyclic ring； bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring；and bicyclic group consisting of benzene ring fused with -or 6-membered non-aromatic heterocyclic ring having 1 or 2heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring；R represents H or –CH 3；x is 0 or 1；yis 2 or 3；and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents –CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.Dérivés Sulfonamides de la benzylamine de formule (I), dans laquelle A représente un groupe phényle non substitué ou substitué； ou un groupe bicyclique à 9 ou 10 chaînons
