KOLACZKOWSKI, MARCIN,BUCKI, ADAM,PAWLOWSKI, MACIEJ,MARCINKOWSKA, MONIKA,LYSAKOWSKI, TOMASZ
申请号：
MX2014011315
公开号：
MX2014011315A
申请日:
2013.03.20
申请国别(地区):
MX
年份:
2014
代理人:
摘要：
Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substitutedor 9-or 10-membered bicyclic group, linked to –(O) x - (CH 2 ) y -through one of its aromatic carbon atoms,consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5-or 6-membered non-aromaticheterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C1 -C3 - alkyls D represents a group selected from:phenyl unsubstituted or substituted naphthyl unsubstituted or substitutedthiophene unsubstituted or substitutedbicyclic group consisting of imidazolering fused with5-membered non-aromatic carbocyclic ring bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ringand bicyclic group consisting of benzene ring fused with -or 6-membered non-aromatic heterocyclic ring having 1 or 2heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ringR represents H or –CH 3x is 0 or 1yis 2 or 3and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents –CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.Derivados de sulfonamida de bencilamina de fórmula (I), (ver Fórmula) en donde A representa fenilo no sustituido o sustituido o grupo bicíclico de -9- o 10-miembros, enlazado a
