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TETRAZOLIC COMPOUNDS FOR REDUCING URIC ACID CONCENTRATION
专利权人:
ВЕЛЛСТАТ ТЕРАПЬЮТИКС КОРПОРЕЙШН (US)
发明人:
О'НЕЙЛ Джеймс Деннен (US),ШАРМА Шалини (US),АРУДЧАНДРАН Рамачандран (US),ОНЕЙЛ Джеймс Деннен (US)
申请号:
RU2010148762/04
公开号:
RU2010148762A
申请日:
2009.04.30
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. The compound represented by formula XLVI! ! where x is 1 or 2:! y is 0, 1, 2, or 3:! R1 is selected from the group consisting of hydrogen, alkyl, containing 1 or 2 carbon atoms, hydroxy, alkoxy, containing 1 or 2 carbon atoms, fluorine, chlorine, bromine and amino; and! A represents phenyl unsubstituted or substituted by one, two or three groups selected from the group consisting of halogen, alkyl containing 1 or 2 carbon atoms, perfluoromethyl, alkoxy containing 1 or 2 carbon atoms, and perfluoromethoxy; or a 5- or 6-membered heteroaromatic ring containing in the ring 1 or 2 heteroatoms selected from N, S and O, the heteroaromatic ring being covalently linked to the rest of the compound via a ring carbon atom. ! 2. The compound according to claim 1, represented by formula XLVII! ! where x is 1 or 2; ! y is 0, 1, 2 or 3; ! one of R2 and R3 represents hydrogen, and the other is selected from the group consisting of hydrogen, alkyl, containing 1 or 2 carbon atoms, hydroxy, alkoxy, containing 1 or 2 carbon atoms, fluorine, chlorine, bromine and amino; and! A is phenyl unsubstituted or substituted by one, two or three groups selected from the group consisting of halogen, alkyl containing 1 or 2 carbon atoms, perfluoromethyl, alkoxy containing 1 or 2 carbon atoms, and perfluoromethoxy; or a 5- or 6-membered heteroaromatic ring containing in the ring 1 or 2 heteroatoms selected from N, S and O, the heteroaromatic ring being covalently linked to the rest of the compound via a ring carbon atom. ! 3. The compound according to claim 1 or 2, where x is equal to 1.! 4. The compound according to claim 3, where A is phenyl, unsubstituted or substituted by one, two1. Соединение, представленное формулой XLVI ! ! где x равно 1 или 2: ! y равно 0, 1, 2 или 3: ! R1 выбирают из группы, состоящей из водорода, алкила, содержащего 1 или 2 атома углерода, гидрокси, алкокси, содержащего 1 или 2 атома углерода, фтора, хлора, брома и амино; и ! A представляет собой фенил, незамещен
来源网站:
中国工程科技知识中心
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