BRODNEY, MICHAEL,CARON, STEPHANE,HELAL, CHRISTOPHER,RAGGON, JEFFREY,TAO, YONG,DO, NGA
申请号：
ES05708687
公开号：
ES2374629T3
申请日:
2005.03.07
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of the formula in which R1 is a group of the formula G 5 1 or G2 represented below, a is zero to eight； m is one to three； R6 is selected from the group consisting of hydrogen, (C1-C6) alkyl optionally substituted with (C1-C6) alkoxy or one to three fluorine atoms, or aryl ((C1-C4) alkyl) in which the aryl moiety is phenyl , naphthyl or heteroaryl- (CH2) q-, wherein the heteroaryl moiety is selected from the group consisting of pyridyl, pyrimidyl, benzoxazolyl, benzothiazolyl, benzoisoxazolyl and benzoisothiazolyl and q is zero, one, two, three or four and in which said aryl and heteroaryl moieties may be optionally substituted with one or more substituents independently selected from the group consisting of chlorine, fluorine, bromine, iodine, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, cyano and -SOtalkyl ( C1-C6), where t is zero, one or two； each of R13 is independently (C1-C4) alkyl or an (C1-C4) alkylene bridge from one of the ring carbon atoms of the piperazine or piperidine ring of G1 or G2, respectively, to the same or another ring carbon atom or a ring nitrogen of piperazine or piperidine ring of G1 or G2, respectively, having an available binding site, or a ring carbon atom of R6, when R6 has a ring structure have a binding site available； X is hydrogen, chlorine, fluorine, bromine, iodine, cyano, (C1-C6) alkyl, hydroxy, (C1-C6) alkoxy, -SOtalkyl (C1-C6) where t is zero, one or two, -CO2R10 or - CONR11R12； each of R10, R11 and R12 is independently selected from hydrogen, (C1-C4) alkyl, phenyl and naphthyl, said phenyl or naphthyl being optionally substituted with one or more substituents independently selected from chlorine, fluorine , bromine, iodine, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, cyano and (C1-C6) alkyl where t is zero, one or two； or R11 and R12, together with the nitrogen to which they are attached, form a 5- to 7-membered heteroalkyl ring that may contain from zero to four heteroatoms selected from nitrogen, sulfur an
