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СУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ БЕНЗИЛАМИНА ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ ЦНС
专利权人:
ADAMED SP. Z O.O.
发明人:
KOLACZKOWSKI Marcin,MARCINKOWSKA Monika,BUCKI Adam,LYSAKOWSKI Tomasz,PAWLOWSKI Maciej,Колачковский, Марцин,Марцинковская, Моника,Буцкий, Адам,Лысаковский, Томаш,Павловский, Мацей
申请号:
EA201491707
公开号:
EA024767B1
申请日:
2013.03.20
申请国别(地区):
EA
年份:
2016
代理人:
摘要:
Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted; or 9- or 10-membered bicyclic group, linked to -(O)-(CH)- through one of its aromatic carbon atoms, consisting of benzene ring fused with 5-membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5- or 6-membered non-aromatic heterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C-C-alkyls; D represents a group selected from phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted; thiophene unsubstituted or substituted; bicyclic group consisting of imidazole ring fused with 5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2 heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring; and bicyclic group consisting of benzene ring fused with 5- or 6-membered non-aromatic heterocyclic ring having 1 or 2 heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring; R represents H or -CH; x is 0 or 1; y is 2 or 3; and pharmaceutically acceptable salts and solvates thereof, with the proviso that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with 1 halogen atom, and if R represents -CH, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.В изобретении представлены сульфонамидные производные бензиламина формулы (I), где А представляет собой фенил, незамещенный или замещенный; или 9- или 10-членную бицикличе
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