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SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES
专利权人:
ADAMED SP. Z O.O.;아다메드 에스피. 제트 오.오.
发明人:
KOLACZKOWSKI MARCIN,콜락츠코브스키, 마르친,MARCINKOWSKA MONIKA,마르친코브스카, 모니카,BUCKI ADAM,부키, 아담,LYSAKOWSKI TOMASZ,리사코브스키, 토마즈,PAWLOWSKI MACIEJ,파블로브스키, 마치에즈
申请号:
KR1020147029232
公开号:
KR1020140135835A
申请日:
2013.03.20
申请国别(地区):
KR
年份:
2014
代理人:
摘要:
Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted; or 9- or 10-membered bicyclic group, linked to —(O)x—(CH2)y— through one of its aromatic carbon atoms, consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5- or 6-membered non-aromatic heterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C1-C3-alkyls; D represents a group selected from: phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted; thiophene unsubstituted or substituted; bicyclic group consisting of imidazolering fused with 5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2 heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring; and bicyclic group consisting of benzene ring fused with—or 6-membered non-aromatic heterocyclic ring having 1 or 2 heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon N atoms of benzene ring; R represents H or —CH 3; x is 0 or 1; y is 2 or 3; and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents —CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.본 발명은 하기 일반식 (I)의 화합물, 및 이의 약제학적으로 허용가능한 염 및 용매 화합물에 관한 것이다.[일반식 (I)]상기 일반식 (I)에서,A는치환되거나 비치환된 페닐을 나타내거나;N 및 O로 이루
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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