Kolaczkowski, Marcin,Marcinkowska, Monika,Bucki, Adam,Lysakowski, Tomasz,Pawlowski, Maciej
申请号：
UAA201411311
公开号：
UA112109C2
申请日:
2013.03.20
申请国别(地区):
UA
年份:
2016
代理人:
摘要：
Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted；or 9- or 10-membered bicyelic group, linked to -(O)x -(СH2)y-through one of its aromatic carbon atoms, consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5- or 6-meinbered non-aromaticheterocyclic ring having 1 or 2 О atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C1-C3-alkyls； D represents a group selected from: phenyl unsubstituted or substituted； naphthyl unsubstituted or substituted； thiophene unsubstituted or substituted； bicyclic group consisting of imidazolering fused with 5-membered non-aromatic carbocyclic ring； bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2 heteroaloms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring； and bicyclic group consisting of benzene ring fused with -or 6-membered non-aromatic heterocyclic ring having 1 or 2 heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring； R represents H or CH 3； x is 0 or 1； yis 2 or 3； and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and у is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents СH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.Сульфонамідні похідні бензиламіну загальної формули (І): EMBED ISISServer (I), де А являє собою: феніл, не заміщений або заміщений одним замісником, вибраним з групи,
