Provided is a plasma purification device that can easily collect blood and plasma remaining in a plasma purification device after the completion of plasma purification therapy without fear of coagulation. A plasma purification apparatus continuously operates without stopping a blood pump at the end of plasma purification, and sends blood to the blood side space of the plasma separator, while the pressure in the filtration side space of the plasma separator is reduced to blood. The flow rate of the air pump and the plasma pump is controlled so as to be higher than the pressure of the side space, and the plasma remaining in the filtration side space of the plasma separator is supplied to the blood side space of the plasma separator or by the supply of air from the air pump. Control means for delivering to the plasma circuit.【課題】血漿浄化療法の終了後、血漿浄化装置内に残された血液と血漿を、凝固の恐れなく、簡便に回収できる血漿浄化装置を提供する。【解決手段】血漿浄化装置は、血漿浄化終了時に血液ポンプを停止することなく引き続き作動させて、血液を血漿分離器の血液側空間に送出させつつ、血漿分離器の濾過側空間の圧力が血液側空間の圧力より高くなるようにエアポンプと血漿ポンプの流量を制御して、血漿分離器の濾過側空間に残されている血漿を、エアポンプからの空気の供給により血漿分離器の血液側空間または血漿回路に送出させる制御手段を有する。