ЗАКУТО Майкл Дж. (US),ДАНН Роберт Ф. (US),МОМЕНТ Аарон Дж. (US),ДЖЕЙНИ Джейкоб М. (US),ЛИБЕРМАН Дэвид (GB),ШИН Фэй (GB),БРЕМЕЙЕР Надин (GB),СКОТТ Джереми (GB),КУТ Джеффри Т. (US),ТАНЬ Луши (US),ЧЭНЬ Ц
申请号：
RU2014102764/04
公开号：
RU2014102764A
申请日:
2012.06.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A process for preparing a compound of structural formula I: wherein Rvybirayut from the group consisting of Ci ^ alkyl and Ctsikloalkila, and W is hydrogen or P, where P is an amino protecting group, or wherein R is hydrogen or P, where P is an amino protecting group, sulfonylation comprising a compound of formula III: and isomerization of the mixture of compounds of formula I and formula I: wherein said compound of formula III sulfonylation and isomerization sulfonylated compounds of formula III comprises mixing a compound of formula III with sulfonylating agent, and at least one base, at least one suitable organic rastvoritele.2. A method according to Claim. 1, wherein said method is carried out as a one step protsess.3. A method according to claim. 2, wherein said compound of formula III sulfonylation and isomerization mixture sulfonylated compounds I and I comprises mixing a compound of formula III, sulfonylating agent and a suitable base in a suitable rastvoritele.4. A method according to claim. 3, wherein said sulfonylating agent is MsCl, said base is NaHMDS, and said solvent comprises a mixture of THF and DMFA.5. A method according to Claim. 1, wherein said method is carried out as a two step protsess.6. The method of claim. 5, where the first step is a sulfonylation of a compound of formula III, comprising mixing a compound of formula III, sulfonylating agent, first base and a suitable first rastvoritelya.7. A method according to claim. 6, wherein said sulfonylating agent is MsCl, said first base is TEA, and said first solvent representation1. Способ получения соединения структурной формулы I:где R2 выбирают из группы, состоящей из C1-6алкила и C3-6циклоалкила, иW представляет собой водород или P, где P представляет собой аминозащитную группу, илигде R3 представляет собой водород или P, где P представляет собой аминозащитную группу,включающий сульфонилирование соединения формулы III:и изомеризацию смеси соединений формулы I и формулы I:где указанное сульф
